The purpose of this notice of funding opportunity (NOFO) is to support the establishment of multidisciplinary Tuberculosis (TB) Research Units (TBRUs) that will operate as a collaborative network to improve understanding of Mycobacterium tuberculosis (Mtb)-host interactions through characterizing the
roles of bacterial and host heterogeneity on infection outcomes and disease progression, and defining bacterial and host determinants relevant to Mtb establishment, dissemination, and disease stage.